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 Phage Therapy for Prostatitis 
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Joined: Sun Mar 03, 2013 8:58 am
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Post Phage Therapy for Prostatitis
Does anybody know anything about this? Phages are viruses that attack and kill bacteria. They have been using this treatment in the former Soviet Union (Georgia) for 90 years. There are some papers on it available online. Basically if you can identify the bacteria in your prostate you can have a lab make a phage for you to treat it. Thats my very limited understanding by looking online. No worries with antibiotic reisistance side effects etc.
Any experts out there?


Thu Mar 21, 2013 8:51 am
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Joined: Sat Dec 08, 2012 4:30 am
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Post Re: Phage Therapy for Prostatitis
Steve wrote:
Does anybody know anything about this? Phages are viruses that attack and kill bacteria. They have been using this treatment in the former Soviet Union (Georgia) for 90 years. There are some papers on it available online. Basically if you can identify the bacteria in your prostate you can have a lab make a phage for you to treat it. Thats my very limited understanding by looking online. No worries with antibiotic reisistance side effects etc.
Any experts out there?


Interesting post Steve. Never heard of this treatment but apparently it isn't approved outside of Georgia. Not sure why because from what little I read it seems to target only a specific bacteria without all the side effects of antibiotics. Also you would think this would be relatively easy to do if you could identify bacteria.


Thu Mar 21, 2013 1:26 pm
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Post Re: Phage Therapy for Prostatitis
So... I have a CBP with a ESBL E.Coli (bingo) over 3 years.
Have try everything (10000 antibiotics, injection directly in prostata etc.)
But now will try the phagetherapy in Poland.
Have write to
Bacteriophage Laboratory, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
And become very rush a answer from Dr.Ryszard Międzybrodzki. Now i send first the prostate exprimate and they try to isolate bacteria and then they typing the phage specialy for it.
And is it not so expensive as i think.
http://prostatitis.org/redirect.php?lin ... elSy_o1m2g

Sorry for my English (i'm from Germany)
Maybe its help someone and me
Regards

Maxim

ADMIN NOTE: This is a pdf and it appears safe to open. I encountered no issues when I opened it.


Fri Apr 25, 2014 5:57 pm
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Joined: Fri May 31, 2013 7:32 pm
Posts: 136
Post Re: Phage Therapy for Prostatitis
Deepmaxim hope you don't mind me asking?

Do you have contant fever and flu like symptoms
do you have fatigue?
are you in contant pain
Are you on anti depressants and pain killers?
When you say you have Chronic baterial prostratitis do you have recurrent urinary tract infections?


Sat Apr 26, 2014 7:22 am
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Post Re: Phage Therapy for Prostatitis
max, are your cultures always positive?


Sat Apr 26, 2014 8:33 am
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Post Re: Phage Therapy for Prostatitis
Wow... so much questions... :)
Ok i try to explain my story (but sorry for my language)
It was 2011, the first simptoms was like "normal" urethritis, pain and burn in urethra/pelvis.
I was directly by my urologist (first one). Have became doxycycline for 3 weeks. It was little bit better, but burning and pain go higher and 3 weeks later have typical simptoms from prostatitis. So... all syptoms is difficult to explain. But burning in perianal region, burning in prostata region. Later - erektion problem. Next antibiotics was Ciprofloxacin for 4 weeks, culture first negative.
2 Weeks later all the symptoms are back... Than TMX (Trimethoprim/sulfamethoxazole) for 6 weeks. Nothing
Then i became pylonephritis left side, it was in Egypt (diving) and i must stay for 5 days in Egypt hospital. Have become Ceftriaxone. Flight back to Germany, from airplane directly to University Klinik in Aachen. In urin they have found E.Coli with ESBL properties. Bad news huh...
Have became Imipinem for 7 days. Pylonephitis cured. Nice. Prostatis symptoms was better. But in one week...
Yes, all symptoms back.
Other Hospital - became High Resolution MRT for prostata. Nothing... Eerything is ok. But ESBL E.Coli in sperma... Then was Meropenem+Fosfomycin i.v. for 4 weeks. One weeks was without any symptoms, then all was back. New results from Labor - my E.Coli is present.... Fuuuuuu....
4 Weeks Tygecyclin... Vomoting, cann not eating, 5kg body weight away. After tygecyline was for 3 weeks ok... No pain, no burning, nothing... then... all was back.
Another Urologist - injection antibiotica in prostata (transrectal) , better but after 2 week - pain, burning

Have order in Japan (over German pharmacy) Sitafloxacin (it must work on ESBL bacterium)- 2000€ pay for it.
Without any effect. That was in Februar and it was my last hope. :( Nothing has for for me. Nothing!!! I'm 38 old man.....
Problem is (?) Biofilm that produced E.coli. becouse anatomicly is by me ok...

Earlier have read about bacteriophage... Maybe that will work for me. Maybe not, but i try it!!! Have nothing to lose... Without this is my next station - TURP... but i dont wont it...
So... that is my story and sorry for bad english :)


Sat Apr 26, 2014 4:11 pm
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Post Re: Phage Therapy for Prostatitis
2Shaky
No, not allways. Just in 30% , becouse my Immunsystem push it down. But after ACC was in 80% bacteriuminside a prostata fluid


Sat Apr 26, 2014 5:31 pm
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Post Re: Phage Therapy for Prostatitis
Very few people on this forum have infected urine or have had a kidney infection!
Most have just got non bacterial prostratitis and will never have the pleasure of that condition
Its good that they could cure you of the kidneyinfection with antibiotics so you are safe from that
in the future!
you didn't answer my question I put to you before
Do you feel ill all the time
Do you have constant fever and chills?
do you have fatigue?
Does your urine smell foul?
Is the pain intense?
Do you feel depressed?
I find doctors never ask these questions
In time your condition will settle down.


Sat Apr 26, 2014 6:34 pm
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Post Re: Phage Therapy for Prostatitis
Deepmaxim,

Your English is fine. Thanks for sharing your story.


Sat Apr 26, 2014 7:54 pm
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Post Re: Phage Therapy for Prostatitis
pg123 wrote:
Very few people on this forum have infected urine or have had a kidney infection!
Most have just got non bacterial prostratitis and will never have the pleasure of that condition
Its good that they could cure you of the kidneyinfection with antibiotics so you are safe from that
in the future!
you didn't answer my question I put to you before
Do you feel ill all the time
Do you have constant fever and chills?
do you have fatigue?
Does your urine smell foul?
Is the pain intense?
Do you feel depressed?
I find doctors never ask these questions
In time your condition will settle down.


I feel ill 80% the time
Fever and chils - about 60-80% time dayli
Fatigue... no
Urine smells like... urine. I think is normal.
sometimes is pain intense (after sex as example), sometimes no so intense
Depressed? No i dont think so... I know, that i have a big problem, i cann manage this in my head
Why you asked me about this? I think each man with a CBP has the same symptoms....


Sun Apr 27, 2014 8:22 pm
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Post Re: Phage Therapy for Prostatitis
So you have ecoli...Where do you get lab test? Probably not in North America.... Over you would be considered with non bacterial prostatitis.

So what do doctor suggest you?


Sun Apr 27, 2014 9:40 pm
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Post Re: Phage Therapy for Prostatitis
Shaky wrote:
So you have ecoli...Where do you get lab test? Probably not in North America.... Over you would be considered with non bacterial prostatitis.

So what do doctor suggest you?


where? In Germany, Israel etc.
in Germany i was in few University Hospitals (Aachen, Münster, Dortmund) they all have found e.coli.


Mon Apr 28, 2014 4:11 am
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Post Re: Phage Therapy for Prostatitis
People don't understand this I don't know why!

Chronic Bacterial prostratitis = recurrent Urinary tract infections
Non bacterial prostratitis = no urinary tract infection

Thats all that matters
Most middle age men have an infection that will settle down
There is no cure.
If for some strange reason it doesn't get better there are antidepressants
and pain killers to take. You could even get morphine is you are really suffering
It seems that some people have an active life (sexual and physical) when they
are ill with this condition and see no reason to resort to mood controlling medicine.


Mon Apr 28, 2014 8:42 am
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Joined: Fri Apr 25, 2014 5:38 pm
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Post Re: Phage Therapy for Prostatitis
pg123 wrote:
People don't understand this I don't know why!

Chronic Bacterial prostratitis = recurrent Urinary tract infections
Non bacterial prostratitis = no urinary tract infection

Thats all that matters
Most middle age men have an infection that will settle down
There is no cure.
If for some strange reason it doesn't get better there are antidepressants
and pain killers to take. You could even get morphine is you are really suffering
It seems that some people have an active life (sexual and physical) when they
are ill with this condition and see no reason to resort to mood controlling medicine.


Yes, i know thar most mens over 35-45 have (sometimes asymptomatic) prostatitis. Sometimes without any bacterials in urine/prostata expressed fluid/sperma. But its not try, that you can not cure the infection. You must just have a antibiotics, that penetrate the prostata gland. Tim/Sul or fluorchinolone or tetracycline penetrate well the prostata, but if you have resistent strain (like by me) it woul be more difficult to cure....
But i won't give up and i try each possible variants. Next try is a bacteriophage for E.coli
I will write later my expirience with it


Mon Apr 28, 2014 4:54 pm
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Joined: Sat Mar 22, 2014 10:45 am
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Location: Hungary
Post Re: Phage Therapy for Prostatitis
deepmaxim wrote:
Imipinem, Meropenem+Fosfomycin, Tygecyclin... Sitafloxacin


I haven't even heard about the last one.

These are all damned expensive antibios. Good to know I should think twice before spending on these.

Have you tried any kind of immune therapy? There is a medicine called Uro-vaxom in my country. It contains E.Coli lyophilisate which helps to improve the immune reaction of immune cells. You can take it for long, it's not harmful and relatively cheap. It's not a wonder medicine but I feel it helped me somewhat.


Wed Apr 30, 2014 11:21 am
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Post Re: Phage Therapy for Prostatitis
fhouse wrote:
deepmaxim wrote:
Imipinem, Meropenem+Fosfomycin, Tygecyclin... Sitafloxacin


I haven't even heard about the last one.

These are all damned expensive antibios. Good to know I should think twice before spending on these.

Have you tried any kind of immune therapy? There is a medicine called Uro-vaxom in my country. It contains E.Coli lyophilisate which helps to improve the immune reaction of immune cells. You can take it for long, it's not harmful and relatively cheap. It's not a wonder medicine but I feel it helped me somewhat.


Yep, have take" Urovoxom", and have injected "Strovac" (for immunization too). Sadly, not work for me.


Wed Apr 30, 2014 3:09 pm
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Post Re: Phage Therapy Procedure Infos
I'm currently doing a phage therapy at the Hirtzfeld Institute in Wroclaw/Poland, Polish Academy of Sciences.

My prostate fluid is infected with enterococcus faecalis, enterobacter cloacae and klebsiella pneunominae... I'm suffering for about two years now and all antibiotic treatments, including those with so-called last-line-of-defense-antibiotics like imipenim and teicoplanin brought zero result. So did not transurethral resection of the prostate.

In Germany, I couldn't find a doctor doing intraprostatic injections of antibiotics but after a long journey I finally found one offering me radical prostatectomy if the phages wouldn't succeed... besides the fact that he'd be doing prostatectomy for prostatitis the first time...
So I hope phage therapy will do...

I would love to hear from anybody, especially those who did bacteriophage therapy for prostatitis, what to pay attention to during therapy.
I'm meaning those facts doctors and medical team members often ignore... you know what I mean.
First of all, this is important during phage typing in laboratory (currently running) and, after that, during home application, in whatever form it may be...

I will report what happened during therapy.
Keep strong, you're not alone but only you can keep your focus...


Thu Sep 13, 2018 1:54 am
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Post Re: Phage Therapy for Prostatitis
It's odd that you have exactly the same 3 pathogens that were detected in my cultures. Let's see if the phage therapy works in your case.


Thu Sep 13, 2018 7:36 am
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Post Re: Phage Therapy for Prostatitis
It's interesting that all 3 of the bacteria you are diagnosed with are the facultatively anaerobic type. E. faecalis is gram-positive, while the other 2 are gram-negative (this has to do with how they stain on a microscope slide). Facultatively anaerobic basically means they can grow in low-oxygen conditions. Here's a quote from Wikipedia:

"Enterobacter cloacae is a member of the normal gut flora of many humans and is not usually a primary pathogen.[5] Some strains have been associated with urinary tract and respiratory tract infections in immunocompromised individuals. Treatment with cefepime and gentamicin has been reported.[6]"

Taico, have you checked into gentamicin? I also read that E. faecalis is becoming vancomycin-resistant. It's well-researched that multiple species, especially pathogenic ones, can form biofilms in combination. If you have multiple pathogens causing the problems, then it may be smart to inquire what phages would do in such a case. Are they engineering a phage, or more than one phage, to combat all 3 bacteria?


Sun Sep 16, 2018 1:23 pm
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Post Re: Phage Therapy for Prostatitis
Taico, are you able to provide any updates to your journey?


Fri Oct 12, 2018 3:03 am
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Post Re: Phage Therapy for Prostatitis
never had gentamicin. noted that as an option, thanks.
phage therapy starts day after tomorrow. 3 phages against all bacteria and the already had it in their database. daily rectal home self-application. will post the very details next week, including $. if if does not work there is a german urologist who said he then would eventually ex the prostate fully. he would communicate with U.S. k(r?)ongard institute in order to do so. i collected a bundle of ca 200 academic papers on phage therapy, especially for prostatitis and my pathogens. ca 10 offered real benefit; details what to ensure in order to grt max outcome. there was no term i could not find via google books in springer medical press, thieme and blackwell. i only use evidence-based sources. do not trust wiki information when a sentence is not linked to an academic source. will upload the bundle next 1-2 weeks. so phages will start day after tomorrow, tomorrow i travel again to wroclaw, poland to get the phages. will let you know the details. btw i found out that a worm water bottle between my legs helps more against the pain then opioids. keep strong...


Tue Oct 23, 2018 3:43 pm
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Post Re: Phage Therapy for Prostatitis
Taico - I am interested in your story (and I am sure others are as well). Do you have any updates?


Wed Nov 07, 2018 10:18 pm
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Post Re: Phage Therapy for Prostatitis
Here is a recent article about a man who treated his prostatitis with phage therapy:

ADMIN NOTE: As posted someplace here, I can't allow external links for now. Your article was a good one. If someone wants it, PM this poster. THANKS!

"How I defied the doctors' prognosis and found treatment for an 'incurable' superbug"

I was only 33, and my doctor had asked me to learn to live with the debilitating pain in my pelvic region and constant low-grade fever. There were two options before me – listen to him or find my own treatment.

I chose the second option.

All I knew was I had a stubborn infection in my prostate which refused to respond to the five very potent antibiotics.

It started as a dull pain in my pelvic region. I thought it was a muscular stiffness and would get okay during my upcoming trekking trip into the Himalayas. But during the trip, I found I was feeling unusually exhausted.

When I came back to Delhi and realized that I was having to wear a sweat-shirt in 45 degree C heat due to growing weakness and a sensitivity to cold, I knew there was something wrong and it was time to consult a doctor. My doctor diagnosed it as Prostatitis, an infection in the prostate and prescribed me an antibiotic. He did it without any culture and sensitivity test, and I was not convinced of his diagnosis, and his prescription. I decided to seek a second opinion.

The second doctor confirmed his diagnosis and prescribed 2 antibiotics, Azithromycin, and Doxycycline for 10 days. Though he, too, did it without any detailed testing, I decided to go ahead with the treatment. The ten-day course of two potent antibiotics didn't relieve any of the symptoms. During this time, I developed a low-grade fever. On my second visit to my doctor after finishing the initial antibiotics course, he changed the antibiotic to Ofloxacin, which I had to take for 4 weeks.

My digestive system went for a toss because of the heavy dose of antibiotics. I was too tired to carry out my routine work; a nap in the afternoon became essential. I hired an assistant for my work, as I couldn't regularly attend office.

The whole attitude that doctors had towards my problem was just not convincing. Why wouldn't they go for some more detailed testing to confirm the exact organism causing the infection? I was becoming irritable and angry. The side-effects of antibiotics were getting worse and so, I decided to meet yet another doctor.

Meanwhile, I started some research online about my condition. The first search I did was on the diagnostic tests one should undergo in case of prostatitis. One research paper wrote about the prostate fluid test. On my second visit to my new doctor, I asked about the test but he too was not very keen on conducting that test. Rather, he changed my antibiotics to Ciprofloxacin and Amikacin.

I was confused and my condition was worsening. My need to find out the exact bacteria was growing by the day and I wanted an exact answer. Through a friend’s reference, I met a doctor who agreed to conduct a prostate fluid test. The test results found Staphylococcus haemolyticus and Enterococcus faecalis. Enterococcus faecalis is one of the 12 priority pathogens in the WHO's list released in 2017. He told me that I had a superbug infection, which was resistant to many available antibiotics.

I was shocked to see the report. I was never admitted to any hospital, so how did I have an antibiotic-resistant infection? The doctor suggested that my wife should also undergo tests to rule out the presence of these life-threatening bacteria in her body and thankfully, she tested negative.

My doctor told me that it would be difficult to treat this infection as the bacteria were resistant to antibiotics. But he assured me that the chances of infection spreading to the other parts of the body were minimum. The prostate gland is enclosed inside a membrane and disconnected from the rest of the body. In fact, that was one of the main reasons why antibiotics could not penetrate the prostate gland and eliminate the bacteria inside.

The doctor told me that that I may have to live with the condition, manage my symptoms, and bear the pain for life. I was only 33 then, how could I live the rest of my life feeling sick all the time?

I had a growing sense of anger within me. Why did such a disease with no cure happen to me?

Medical science has taken such great leaps forward in some fields – we all know of medical marvels, a possible cure for cancer, advancements in surgeries etc. And here I had a tiny but untreatable bacterial infection in my body. How could that be possible? I had many such questions in my mind to which there were no answers.

I took matters in my own hands and began my research to find a cure for my problem. In the process, I found a number of credible medical journals from where I gathered a lot of reliable information.

I came across Bacteriophage therapy in one research paper published by the National Institutes of Health, USA. They wrote that bacteriophages are friendly viruses that feed on bacteria. It was an age-old therapy in some eastern European countries.

I contacted doctors in the US to know about the treatment. They told me that bacteriophages are a popular modality of treatment in the former Soviet Union, but the treatment is not approved by the US FDA. I got a similar response from the Pasteur Institute of Paris. In fact, a French scientist from this institute was the discoverer of bacteriophages and was involved in the development of bacteriophage therapy in the early 1900s in the country of Georgia.

I read about the treatment in many prestigious medical journals, read about how it was developed by two scientists in Georgia almost a century back, and how it could be the only solution to the growing problem of antibiotic resistance.

These findings gave me a glimmer of hope. Maybe I could find a cure for my untreatable infection that had crippled me by now.

Next, I contacted doctors at an institute of phage therapy in Georgia. They asked me to send my reports and visit their centre in Georgia for the treatment. I had never been in a situation like this. Traveling to another country for treatment was a little scary. I didn't know the language, I didn't know anybody there.

But as there was no alternative, I decided to travel to Tbilisi, the capital city of Georgia in November 2016 with my wife. They conducted three tests — cultures of the prostate fluid, semen and blood sample. Five days later, they confirmed the presence of four bacteria in my prostate – Staphylococcus haemolyticus, Staphylococcus aureus, Streptococcus mitis and Enterococcus faecalis. Out of these four, two were highly resistant to available antibiotics. So, as it turned out I had not one, but two superbugs!

Their standard phage preparations were sensitive against three of these four bacteria. They administered the medicine in three different ways — orally, rectally and in the urethra.

On the fourth day of the therapy, my fever disappeared. The pain in my pelvis, groin, and flank eased a bit in the next three weeks that I stayed there. I came back with medicine for the next two-and-a-half months.

When I went back after completing the course, two bacteria were eliminated and the third one — Enterococcus faecalis – was reduced considerably. But the Streptococcus mitis continued to show resistance to the standard phage preparations. So, the institute had to make a customized phage preparation for it, which would take two months to prepare. In the meanwhile, they asked me to continue my treatment with the standard phage cocktails for another three weeks to get rid of the remaining Enterococcus faecalis.

By the end of these three weeks, I had started feeling almost normal. My sensitivity to cold vanished. My fever disappeared. Symptoms like frequent urination and exhaustion were resolved. The pelvic pain was not that troublesome anymore.

In November 2017, I underwent the final course of treatment with the custom phage to eradicate the Streptococcus mitis, the fourth and final bacteria in my prostate. In May this year, I repeated all the tests and was thrilled to find that there was no trace of bacteria in my prostate fluid. The superbugs had been successfully defeated.
_________________________________________________________________________________________________


Wed Nov 14, 2018 1:00 pm
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Post Re: Phage Therapy for Prostatitis
Met this guy in real life, he is a real cool truthful guy.

However, his case will not apply to 98% of you.

Phages work usually in acute phase of infection only (this is what another patient was told at Polish phage center). Do you have a daily fever? I sure don't. We are in chronic state, not acute like him.

I've spoken to many other people that have undergone phage therapy. Not a single success story on this level. Some got a little better. One got worse. Most no changes. No one that I know is cured.


Thu Nov 15, 2018 2:04 pm
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Post Re: Phage Therapy for Prostatitis
dom_hend wrote:
Met this guy in real life, he is a real cool truthful guy.

However, his case will not apply to 98% of you.

Phages work usually in acute phase of infection only (this is what another patient was told at Polish phage center). Do you have a daily fever? I sure don't. We are in chronic state, not acute like him.

I've spoken to many other people that have undergone phage therapy. Not a single success story on this level. Some got a little better. One got worse. Most no changes. No one that I know is cured.


No Chris, you are wrong.


Wed Nov 28, 2018 5:24 pm
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