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 Uropathogenic Escherichia coli induces chronic pelvic pain. 
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Joined: Thu Nov 04, 2010 11:12 pm
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Post Uropathogenic Escherichia coli induces chronic pelvic pain.
Here is a recent abstract by prostatitis researcher AJ Schaeffer, et al., which suggests that E. coli infection may trigger chronic pelvic pain in men. They used E. coli from a human patient and placed it into mice.

Uropathogenic Escherichia coli induces chronic pelvic pain.
Rudick CN, Berry RE, Johnson JR, Johnston B, Klumpp DJ, Schaeffer AJ, Thumbikat P.
Infect Immun. 2011 Feb;79(2):628-35.

Department of Urology, Northwestern University Feinberg School of Medicine, 16-729 Tarry Building, 303 East Chicago Avenue, Chicago, IL 60611, USA.

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a debilitating syndrome of unknown etiology often postulated, but not proven, to be associated with microbial infection of the prostate gland. We hypothesized that infection of the prostate by clinically relevant uropathogenic Escherichia coli (UPEC) can initiate and establish chronic pain. We utilized an E. coli strain newly isolated from a patient with CP/CPPS (strain CP1) and examined its molecular pathogenesis in cell culture and in a murine model of bacterial prostatitis. We found that CP1 is an atypical isolate distinct from most UPEC in its phylotype and virulence factor profile. CP1 adhered to, invaded, and proliferated within prostate epithelia and colonized the prostate and bladder of NOD and C57BL/6J mice. Using behavioral measures of pelvic pain, we showed that CP1 induced and sustained chronic pelvic pain in NOD mice, an attribute not exhibited by a clinical cystitis strain. Furthermore, pain was observed to persist even after bacterial clearance from genitourinary tissues. CP1 induced pelvic pain behavior exclusively in NOD mice and not in C57BL/6J mice, despite comparable levels of colonization and inflammation. Microbial infections can thus serve as initiating agents for chronic pelvic pain through mechanisms that are dependent on both the virulence of the bacterial strain and the genetic background of the host.

Sat Feb 19, 2011 11:30 pm
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