Prostatitis Abstract January 2011
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Author:  Brad Hennenfent, MD [ Wed Jan 19, 2011 11:07 pm ]
Post subject:  Prostatitis Abstract January 2011

The DABBEC Phenotyping System: towards a mechanistic understanding of CP/CPPS. Nat Rev Urol. 2011 Jan 18.
Allsop SA, Erstad DJ, Brook K, Bhai SF, Cohen JM, Dimitrakoff JD.
Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.

There is an urgent need to elucidate the mechanistic basis of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), as the current methods of symptom-based diagnosis and treatment have failed. Here, we propose a phenotyping system that bridges the gap between the symptom-based diagnosis and treatment of the present and the mechanistic approach of the future. Our phenotyping system uses the Chronic Prostatitis Collaborative Research Network (CPCRN)-recommended algorithm in combination with the NIH Chronic Prostatitis Symptom Index (NIH-CPSI) as a basis for diagnosis, while incorporating novel domains for quantitative assessment and stratification of CP/CPPS patients. We believe this novel system will serve to help advance our understanding of the roles of the patient's genome and proteome in the etiology of CP/CPPS. We predict that, as we begin to understand the mechanistic basis of CP/CPPS pathology and progression, we will develop specific treatments that will aim to cure the disease, rather than merely quell the symptoms.

Unfortunately, I do not have the full paper this abstract goes with. It appears that these authors are trying to study prostatitis symptoms as they relate to the genes that men have, and the proteins that are produced by men's cells. It's great to see this cutting edge research, for I think there is a crisis in prostatitis research that needs to be fixed, but can only be achieved by the activism of patients who want to see that more research gets done. There is little or no research money to fund prostatitis research for my physician colleagues and most researchers of prostatitis.

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